You will find there's launch of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to reduce afferent discomfort transmission and produce analgesia. Consequently, medicine like clonidine that goal alpha-two receptors can influence the transmission of pain. Clonidine is dispersed in breast milk; https://www.proleviate.com/post/the-new-pain-killer-conolidine