Patients who will be now obtaining medicines which can be powerful inducers or inhibitors of CYP3A4 aren't qualified. Strong inducers or inhibitors of CYP3A4 should be averted from fourteen days previous to enrollment to the end of the examine. Experimental: Dose expansion_sub-population 2_higher dose of niraparib MTDs and/or candidate RP2Ds https://nickz221mxi4.izrablog.com/profile